FIG4 rabbit pAb - ES8837

FIG4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8837-50, ES8837-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008],

Alternate Name: Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3, 5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human FIG4. at AA range: 341-390

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 110kD

Human Gene ID: 9896

Human SWISS Prot NO: Q92562

Subcellular Location: Endosome membrane. Localization requires VAC14 and PIKFYVE.

Research Use Only