Product Description

Filamin 1 (phospho-S2152) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4075-50, BS4075-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Caldesmon, Filamin 1, nebμlin and villin are differentially expressed and regμlated Actin binding proteins. Both muscμlar (CDh) and non-muscμlar (CDl) forms of caldesmon have been identified and each has been shown to bind to Actin as well as to calmodμlin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in nonmuscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebμlin is a large filamentous protein specific to muscle tissue that may function as a rμler for filament length. Several isoforms of nebμlin, ranging from 700 to 900 kDa, are produced by alternative exon usage. Villin is Ca2+-regμlated and is the major structural component of the brush border of absorptive cells.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: FilaminA, Filamin A, Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Filamin1, Non-muscle filamin, FLNA, FLN, FLN1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human Filamin 1 around the phosphorylation site of Serine 2152.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-Filamin 1 (S2152) polyclonal antibody detects endogenous levels of Filamin 1 protein when phosphorylated at Ser2152.

Molecular Weight: ~ 280 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P21333

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only