FITC Anti-Mouse CD274/PD-L1 Antibody (10F.9G2)
Sizes: 25μg, 100μg
Catalogue Numbers: FITC-30030U-25, FITC-30030U-100
Citations, Manuals and MSDS Available upon request.
Target: Mouse CD274/PD-L1
Form: Liquid
Conjugation: FITC
Conjugation Information: FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Host: Rat
Clonality: Monoclonal
Clone ID: 10F.9G2
Isotype: IgG2b, κ
Storage: PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Synonyms: B7H1PD-L1PDCD1L1PDCD1LG1PDL1| B7 homolog 1| B7-H| B7-H1| Programmed cell death ligand 1
Uniprot ID: Q9EP73
Reactivity: Mouse
Tested Application: FC
Recommended Dilution: Each lot of this antibody is quality control tested by Flow cytometryometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1μg/10⁶ cells in 100 μL volume].
Gene ID: 60533
Category: Flow cytometryometry Antibodies
Research Use Only