FKBP1A/B Polyclonal Antibody - BT-AP06228

FKBP1A/B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06228-20, BT-AP06228-50, BT-AP06228-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the immunophilin protein family| which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels| and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse| deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants| encoding the same protein| have been identified. The human genome contains five pseudogenes related to this gene| at least one of which is transcribed.

Research Areas: Immunology

Target Protein: fkbp1a

Applications: IHC-p, IF, WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: FKBP1A/B

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P62942/P68106

Synonyms: FKBP1A; FKBP 12; FKBP12; FKBP 1A; FKBP-12; FKBP-1A; FKBP12C; PKCI2; PPIase; PKC12; Rotamase

GeneID: Human: 2280/2281

Research Use Only