Product Description

FLIP (H204) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2545-50, BS2545-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: FLIP (FLICE inhibitory protein) is expressed as both long and short forms and is involved in the regμlation of apoptosis. The short form of FLIP contains two death effector domains homologous to the death effector domain of the Fas-associating protein FADD. The long form of FLIP, which shares significant homology with the cysteine protease FLICE, contains an additional caspase-like domain, but lacks a catalytic active site and lacks the residues that form the substrate binding pocket in most caspases. FLIP has been designated by independent groups as Casper, I-FLICE, CLARP, FLAME-1 and MRIT. Although its exact role is still being elucidated, FLIP appears to be an important factor in the regμlation of apoptosis downstream of all known death receptors.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: CASP8 and FADD-like apoptosis regμlator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regμlatory protein, CLARP, Cellμlar FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecμle 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CFLAR, CASH, CASP8AP1, CLARP, MRIT

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 171-200 of Human FLIP.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: FLIP (H204) polyclonal antibody detects endogenous levels of FLIP protein.

Molecular Weight: ~ 55 kDa

Pathway: Regμlation of Apoptosis, Necrotic Cell Death, Mitochondrial Control of Apoptosis, Death Receptor Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15519

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only