Product Description

Flt3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25019-50, RA25019-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: fms related tyrosine kinase 3 (FLT3) Homo sapiens This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IHC-p, IF (paraffin section), WB

Alternate Names: Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1;FL cytokine receptor;Fetal liver kinase-2;FLK-2;Fms-like tyrosine kinase 3;FLT-3;Stem cell tyrosine kinase 1;STK-1;CD antigen CD135)

Clonality: Polyclonal

Dilution: IHC-p 1:50-200, WB 1:500-2000

Molecular Weight: 115

Protein Molecular Weight (kDa): 115

Storage: -20°C/1 year

Human Gene ID: 2322

Human SwissProt Number: P36888

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only