Product Description

FNDC5 Monoclonal Antibody

Catalogue Numbers: MB67152-50, MB67152-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q8NAU1

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Fibronectins are multi-domain glycoproteins that bind to a variety of substances including collagen, Actin, heparin, DNA, fibrin and Fibronectin receptors. They are involved in a diverse array of important functions such as blood coagulation, wound healing, cell adhesion, cell differentiation and migration. FNDC5 (Fibronectin type III domain containing 5), also known as FRCP2, is a 196 amino acid single-pass type I membrane protein that is imported in peroxisomes through the Peroxin 5 receptor pathway. Existing as four alternatively spliced isoforms, FNDC5 is encoded by a gene located on human chromosome 1p35.1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of FNDC5 protein.

Extra Notes: Western blot analysis of FNDC5 expression in human skeletal muscle (A) whole cell lysates.

Bioworld Molecular Weight: ~ 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: FRCP2; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FNDC5. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified