FOSL2 (S301) Polyclonal Antibody-BS1131

FOSL2 (S301) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1131-50, BS1131-100

Sizes: 50µl, 100µl

Swiss-Prot: P15408

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: FOSL2 (S301) polyclonal antibody detects endogenous levels of FOSL2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of FOSL2 (S301) pAb at 1:500 dilution
Lane 1: The Ovary tissue lysate of Rat (40ug)
Lane 2: The Testis tissue lysate of Mouse (40ug)
Lane 3: PC3 whole cell lysate (40ug)
Lane 4: MCF-7 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of FOSL2 (S301) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Fos-related antigen 2; FRA-2; FOSL2; FRA2

Immunogen: Synthetic peptide, corresponding to amino acids 270-320 of Human FOSL2.

Conjugate: Unconjugated

Modification: Unmodified