Product Description

FoxB1/2 (I72) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2130-50, BS2130-100

Sizes: 50µl, 100µl

Swiss-Prot: Q99853/Q5VYV0

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The Forkhead-box (FOX) genes comprise a superfamily of at least 43 members that encode proteins which are involved in transcriptional regulation and may be associated with the pathogenesis of various cancers. FOXB1 (forkhead box B1), also known as FKH5 or HFKH-5, and FOXB2 (forkhead box B2) are members of the FOX family and each contain one forkhead DNA-binding domain. Both FOXB1 and FOXB2 localize to the nucleus where they are thought to function as transcription factors that can bind to DNA via their forkhead domains. In mice, defects in the gene encoding FOXB1 are associated with retarded development of the central nervous system (CNS), suggesting that FOXB1 may play a role in CNS organization and function.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: FoxB1/2 (I72) polyclonal antibody detects endogenous levels of FoxB1/2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of FoxB1/2 (I72) pAb at 1:500 dilution
Lane 1: Myla2059 whole cell lysate (40ug)
Lane 2: Hela whole cell lysate (40ug)
Lane 3: SGC7901 whole cell lysate (40ug)
Lane 4: The Embryo tissue lysate of Mouse (40ug)
Lane 5: The Testis tissue lysate of Rat (10ug), Immunohistochemistry (IHC) analyzes of FoxB1/2 (I72) pAb in paraffin-embedded human tonsil cancer tissue at 1:50.

Bioworld Molecular Weight: ~ 35,46 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: FKH5; forkhead box B2; Forkhead box protein B1; Forkhead box protein B2; Transcription factor FKH 5;

Immunogen: Synthetic peptide, corresponding to amino acids 40-87 of Human FoxB1.

Conjugate: Unconjugated

Modification: Unmodified