FoxE3 (R97) Polyclonal Antibody-BS2304

FoxE3 (R97) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2304-50, BS2304-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13461

Host: Rabbit

Reactivity: Human, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The human forkhead-box (FOX) gene family consists of at least 43 members, including FOXE3, a 288-amino acid protein. FOXE3 is a winged-helix transcription factor that plays a crucial role during the initial stages of lens development and closure of the lens vesicle. FOXE3 may also act as a factor that promotes survival and proliferation while preventing differentiation in the lens epithelium. As the posterior cells of the lens fiber begin to differentiate, expression of FOXE3 is limited to the undifferentiated cells coating the anterior surface of the lens. Congenital primary aphakia (CPA) is a rare developmental disorder caused by a null mutation in the FOXE3 gene that is identified by the absence of a lens. The development of CPA is normally stimulated during the fourth or fifth week of human embryogenesis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of FoxE3 (R97) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 33 kDa

Specificity: FoxE3 (R97) polyclonal antibody detects endogenous levels of FoxE3 protein.

Alternative Name: Forkhead box protein E3; Forkhead-related protein FKHL12; Forkhead-related transcription factor 8; FREAC-8; FKHL12; FREAC8; FOXE3

Immunogen: Synthetic peptide, corresponding to amino acids 64-116 of Human FoxE3.

Conjugate: Unconjugated

Modification: Unmodified