Product Description

FOXH1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65751-50, BS65751-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regμlated Smad protein, Smad2, and directly binds to activin response elements on DNA (1, 2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regμlating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3, 4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3, 5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adμlt tissues (6, 7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFG?and activin, indicating that these FAST proteins mediate TFG?induced signal transduction (3).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Sheep

Host: Rabbit

Applications: WB

Alternate Names: FAST 1, Fast 2, Fast-1, Fast-2, FAST1, Fast2, Forkhead activin signal transducer 1, Forkhead activin signal transducer 2, Forkhead box H1, Forkhead box protein H1, FOX H1, FOXH 1, FOXH1, FOXH1_HUMAN, hFAST 1, hFAST-1, hFAST1, Human homolog of Xenopus forkhead activin signal transducer 1, TGF beta/Activin signal transducer FAST1.聽

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human FOXH1:41-140/365

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: FOXH1 Polyclonal Antibody detects endogenous levels of FOXH1 protein.

Molecular Weight: 40 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O75593

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only