FoxK1 rabbit pAb - ES5233

FoxK1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5233-50, ES5233-100

Citations, Manuals and MSDS Available upon request.

Background: function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli., PTM:Phosphorylated., similarity:Contains 1 FHA domain., similarity:Contains 1 fork-head DNA-binding domain., subunit:Interacts with SIN3B to form a complex which represses transcription., tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.,

Alternate Name: FOXK1; MNF; Forkhead box protein K1; Myocyte nuclear factor; MNF

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human FOXK1. AA range:681-730

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 78kD

Human Gene ID: 221937

Human SWISS Prot NO: P85037

Subcellular Location: Nucleus. Cytoplasm. Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164).

Research Use Only