Product Description

FOXO4 (phospho-S262) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67196-50, BS67196-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transcription factor involved in the regμlation of the insμlin signaling pathway. Binds to insμlin-response elements (IREs) and can activate transcription of IGFBP1. Down-regμlates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modμlated genes. Also involved in negative regμlation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: AFX, AFX1, MLLT7, Forkhead box protein O4, Fork head domain transcription factor AFX1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FOXO4 with a phosphorylation site at S262. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 157% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of FOXO4 with a phosphorylation site at S262 protein.

Molecular Weight: ~ 70 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P98177

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only