FOXP3 rabbit pAb - ES4176

FOXP3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4176-50, ES4176-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Alternate Name: FOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat; Pig

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP3. AA range:381-430

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 47kD

Human Gene ID: 50943

Human SWISS Prot NO: Q9BZS1

Subcellular Location: Nucleus. Cytoplasm. Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity).

Research Use Only