FPR2 rabbit pAb - ES11464

FPR2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES11464-50, ES11464-100

Citations, Manuals and MSDS Available upon request.

Background: function:Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4)., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Rat; Mouse; ; Swine

Immunogen: Synthesized peptide derived from human protein . at AA range: 130-210

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 38kD

Human Gene ID: 2358

Human SWISS Prot NO: P25090

Subcellular Location: Cell membrane; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011).

Research Use Only