Fra-1 (D134) Polyclonal Antibody-BS1933

Fra-1 (D134) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1933-50, BS1933-100

Sizes: 50µl, 100µl

Swiss-Prot: P15407

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Fra-1 (D134) polyclonal antibody detects endogenous levels of Fra-1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Fra-1 (D134) pAb at 1:500 dilution
Lane 1: PC3 whole cell lysate (40ug)
Lane 2: HepG2 whole cell lysate (40ug)
Lane 3: The Brain tissue lysate of Mouse (40ug)
Lane 4: PC12 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Fra-1 (D134) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 30, 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Fos-related antigen 1; FRA-1; FOSL1; FRA1

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Fra-1.

Conjugate: Unconjugated

Modification: Unmodified