Product Description

FREAC3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65958-50, BS65958-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Binding of FREAC-3 and FREAC-4 to their cognate sites resμlts in bending of the DNA at an angle of 80-90 degrees. Involvement in disease, Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3 (RIEG3), also known as Axenfeld-Rieger syndrome (ARS) or Axenfeld syndrome or Axenfeld anomaly. It is characterized by posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line. Other features may be hypertelorism (wide spacing of the eyes), hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Glaucoma is a progressive blinding condition that occurs in approximately half of patients with Axenfeld-Rieger malformations.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Dog, Cow, Horse

Host: Rabbit

Applications: IHC-P, FCM，

Alternate Names: ARA, FKH L7, FKHL 7, FKHL7, Forkhead (Drosophila) like 7, Forkhead, forkhead box C1, Forkhead box protein C1, Forkhead drosophila homolog like 7, Forkhead like 7, Forkhead related activator 3, Forkhead related protein FKHL7, Forkhead related transcription factor 3, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FOX C1, FOXC 1, FOXC1, FOXC1_HUMAN, FREAC 3, FREAC-3, FREAC3, homolog-like 7, IGDA, IHG 1, IHG1, IRID 1, IRID1, Iridogoniodysgenesis type 1, Myeloid factor delta.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human FOXC1/FREAC3:101-200/553

Dilution: IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test

Purification: affinity purified by Protein A

Specificity: FREAC3 Polyclonal Antibody detects endogenous levels of FREAC3 protein.

Molecular Weight: 57kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q12948

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only