Product Description

Frizzled-10 (FZD10) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2601-50, BS2601-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: Q9ULW2

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB,

All Applications: WB: 1:500~1:1000

Background: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).
The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Frizzled-10 (FZD10) polyclonal antibody detects endogenous levels of Frizzled-10 protein.

Bioworld Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Frizzled-10 (FZD10) polyclonal antibody at 1:500 dilution
Lane 1: EC9706 whole cell lysate (15ug)
Lane 2: Hela whole cell lysate (30ug)
Lane 3: Myla2059 whole cell lysate (15ug)
Lane 4: The Brain tissue lysate of Mouse (30ug)
Lane 5: The Brain tissue lysate of Rat (30ug)
Lane 6: BV2 whole cell lysate (30ug)
Lane 7: PMVEC whole cell lysate (30ug)

Alternative Name: Frizzled-10; Fz-10; hFz10; FzE7; CD350; FZD10

Immunogen: Synthetic peptide, corresponding to Human Frizzled-10.

Conjugate: Unconjugated

Modification: Unmodified