Product Description

Frizzled-2 (E240) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3163-50, BS3163-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellμlar region and a carboxy-terminal Ser/Thr-XXX-Val motif. The proteins in this family function as receptors for Wnt and are generally coupled to G proteins. Frizzleds are members of the G protein-coupled receptor superfamily. Frizzled-2 is expressed in the fetal kidney and lung and in the adμlt ovary and colon. Frizzled-2 mediates the Wnt/cGMP/Ca2+ pathway. It binds Wnt proteins and signals by activating the release of stored calcium. Frizzled-2 expression is regμlated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, and activates NFAT-dependent transcription, the phosphatidylinositol pathway and calcium sensitive enzymes.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: Frizzled 2, Frizzled2, Fz-2, hFz2, FzE2, FZD2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 208-260 of Human Frizzled-2.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Frizzled-2 (E240) polyclonal antibody detects endogenous levels of Frizzled-2 protein.

Molecular Weight: ~ 65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14332

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only