Frizzled-6 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA25111-50, RA25111-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: frizzled class receptor 6 (FZD6) Homo sapiens This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, IF/ICC, ELISA Alternate Names: FZD6, Frizzled-6, Fz-6, hFz6 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. Molecular Weight: 80 Protein Molecular Weight (kDa): 80 Storage: -20°C/1 year Human Gene ID: 8323 Human SwissProt Number: O60353 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only