Frizzled-7 rabbit pAb - ES2373

Frizzled-7 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2373-50, ES2373-100

Citations, Manuals and MSDS Available upon request.

Background: frizzled class receptor 7 (FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],

Alternate Name: FZD7; Frizzled-7; Fz-7; hFz7; FzE3

Source: Rabbit

Applications: WB; Flow Cyt; IF; ELISA

Dilution: WB 1:500-2000; Flow Cyt 1:50-200; IF/ICC 1:100-500; ELISA 1:5000-20000

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 64kD

Human Gene ID: 8324

Human SWISS Prot NO: O75084

Subcellular Location: Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4, 5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.

Research Use Only