Product Description

FRS2 (phospho Tyr436) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25118-50, RA25118-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1., PTM:Phosphorylated on tyrosine residues upon stimulation by NGF., PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination., sequence caution:Translated as stop., similarity:Contains 1 IRS-type PTB domain., subcellular location:Cytoplasmic, membrane-bound., subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11., tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section), ELISA

Alternate Names: FRS2, Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight: 65

Protein Molecular Weight (kDa): 65

Storage: -20°C/1 year

Human Gene ID: 10818

Human SwissProt Number: Q8WU20

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only