Product Description

FSHR (R247) Polyclonal Antibody

Catalogue Numbers:BS2618-50, BS2618-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P23945

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 78 kDa

Specificity: FSHR (R247) polyclonal antibody detects endogenous levels of FSHR protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; LGR1

Immunogen: Synthetic peptide, corresponding to amino acids 215-265 of Human FSHR.

Conjugate: Unconjugated

Modification: Unmodified