FTO rabbit pAb - ES3763

FTO rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3763-50, ES3763-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011],

Alternate Name: FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human FTO. AA range:19-68

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 58kD

Human Gene ID: 79068

Human SWISS Prot NO: Q9C0B1

Subcellular Location: Nucleus. Nucleus speckle. Cytoplasm. Localizes mainly in the nucleus, where it is able to demethylate N (6)-methyladenosine (m6A) and N (6), 2'-O-dimethyladenosine cap (m6A (m)) in U6 small nuclear RNA (snRNA), N (1)-methyladenine from tRNAs and internal m6A in mRNAs (PubMed:30197295). In the cytoplasm, mediates demethylation of m6A and m6A (m) in mRNAs and N (1)-methyladenine from tRNAs (PubMed:30197295).

Research Use Only