GABA B Receptor 2 rabbit pAb - ES20746

GABA B Receptor 2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20746-50, ES20746-100

Citations, Manuals and MSDS Available upon request.

Background: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010],

Alternate Name: GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20

Source: Rabbit

Applications: IHC; IF

Dilution: IHC 1:100-200

Reactivity: Human; Rat; Mouse

Immunogen: Synthetic Peptide of GABA B Receptor 2 AA range: 785-835

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 106kD

Human Gene ID: 9568

Human SWISS Prot NO: O75899

Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.

Research Use Only