Product Description

GAD2 Monoclonal Antibody

Catalogue Numbers: MB66620-50, MB66620-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q05329

Host: Mouse

Reactivity: Human, Rat

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: The enzyme glutamate decarboxylase (GAD) is responsible for the synthesis of the essential neurotransmitter gamma-aminobutyric acid (GABA) from L-glutamic acid. GAD1 (GAD67) and GAD2 (GAD65) are expressed in nervous and endocrine systems and are thought to be involved in synaptic transmission and insulin secretion, respectively. Autoantibodies against GAD2 may serve as markers for type I diabetes. Many individuals suffering from an adult onset disorder known as Stiff Person Syndrome (SPS) also express autoantibodies to GAD2.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of GAD2 protein.

Extra Notes: Western blot analysis of GAD2 expression in rat hippocampus (A), rat brain (B) whole cell lysates.

Bioworld Molecular Weight: ~ 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: GAD65; Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform

Immunogen: Purified recombinant human GAD2 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified