Product Description

GADD45GIP1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61196-50, BS61196-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CRIF1, also known as GADD45GIP1, PLINP1, PRG6 or CKBBP2, is a 222 amino acid nuclear protein that plays a role in apoptosis control. Expressed in a variety of tissues, including heart, thyroid, trachea, kidney, ovary, pancreas, testis and stomach, CRIF1 functions as a negative regμlator of G1 to S phase cell cycle production, specifically by working with GADD 45 proteins to inhibit the activity of cyclin-dependent kinases (Cdks). While overexpression of CRIF1 resμlts in cell cycle arrest at the G1 phase, downregμlation of CRIF1 by p53 in apoptotic cells promotes cell cycle progression and may be an important factor in tumor growth and metastasis. CRIF1 is subject to phosphorylation by casein kinase II, an event that is thought to decrease CRIF1 activity and promote cellμlar proliferation. Human CRIF1 shares 90% homology with its mouse counterpart, suggesting a conserved role between species.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Growth arrest and DNA damage-inducible proteins-interacting protein 1, 39S ribosomal protein L59, mitochondrial, MRP-L59, CKII beta-associating protein, CR6-interacting factor 1, CRIF1, Papillomavirus L2-interacting nuclear protein 1, PLINP, PLINP-1, p53-responsive gene 6 protein, GADD45GIP1, MRPL59, PLINP1, PRG6

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CRIF1.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GADD45GIP1 polyclonal antibody detects endogenous levels of GADD45GIP1 protein.

Molecular Weight: ~ 25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8TAE8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only