GALR2 Polyclonal Antibody - E-AB-91820

GALR2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-91820-60, E-AB-91820-120, E-AB-91820-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: GALR2

Target Synonym: GAL2-R; GALNR2; GALR-2; GALR2

Research Areas: Metabolism, Neuroscience

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Mouse

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: O43603

Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human GALR2

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Observed MW: 47kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only