GALR2 Polyclonal Antibody - RA30641

GALR2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA30641-50, RA30641-100

Citations, Manuals and MSDS Available upon request.

Background: galanin receptor 2 (GALR2) Homo sapiens Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-1000

Alternative Names: GALR2; GALNR2; Galanin receptor type 2; GAL2-R; GALR-2; YM3556

Applications: WB

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 8811

Protein MW (KDa): 42

SWISS: O43603

Source: Rabbit

Research Use Only