GAP43 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90560-50, BS90560-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P17677(Human) P06837(Mouse) P07936(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IHC, IP, , FC
All Applications: WB:1:2,000-1:5,000
ICC:1:100-1:500
IHC:1:100-1:500
FC:1:50-1:100
Background: GAP-43 (growth associated protein 43, B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1 is a crucial component for regenerative response in the nervous system. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The neuron-specific Elav/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons and leads to increased levels of GAP-43 protein. Heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half dipslay significant memory impairments in cued conditioning or on tests of nociceptive or auditory perception.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: GAP43 polyclonal antibody detects endogenous levels of GAP43 protein.
Bioworld Molecular Weight: 48 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of GAP43 on mouse brain lysates using anti-GAP43 antibody at 1/1,000 dilution., ICC staining GAP43 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: GAP43, Axonal membrane protein GAP 43, Axonal membrane protein GAP-43, B 50, Calmodulin binding protein P 57, F1, GAP 43, GAP43, Growth Associated Protein 43, Growth-associated protein 43, Nerve Growth Related Peptide, Nerve growth related peptide GAP43, NEUM, Neural phosphoprotein B 50, Neural phosphoprotein B-50, Neuromodulin, Neuron growth associated protein 43, PP46, Protein F1, QtrA-11580, QtrA-13071,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified