GARS Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90561-50, BS90561-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P41250(Human) Q9CZD3(Mouse) Q5I0G4(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB:1:1,000-1:2,000
IHC:1:50-1:200
Background: The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Proteins belonging to this family function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. GlyRS (Glycyl-tRNA synthetase), also known as Glycine-tRNA ligase, is a 739 amino acid class II synthetase that is widely expressed, including in the brain and spinal cord. Defects in the gene encoding GlyRS is the cause of Charcot-Marie-Tooth disease type 2D (CMT2D), which is an autosomal dominant inherited disease characterized by severe weakness, atrophy and absence of deep tendon reflexes in the upper extremities. Defects in the GlyRS gene is also the cause of distal hereditary muscular neuropathy type V (HMN5), a disease similar to CMT2D, though the distal sensory involvement is less severe in HMN5 patients.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: GARS polyclonal antibody detects endogenous levels of GARS protein.
Bioworld Molecular Weight: 75 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of GARS on Raji cells lysates using anti-GARS antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-GARS antibody. Counter stained with hematoxylin.
Alternative Name: AP-4-A synthetase, GlyRS, GARS, AP 4 A synthetase, Charcot Marie Tooth neuropathy 2D, Charcot Marie Tooth neuropathy neuronal type D, CMT2D, Diadenosine tetraphosphate synthetase, DSMAV, EC 6.1.1.14, Glycine tRNA ligase, Glycyl tRNA synthetase, GlyRS, HMN5, SMAD1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified