Product Description

GAS3 (A142) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1688-50, BS1688-100

Sizes: 50µl, 100µl

Swiss-Prot: Q01453

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

Background: PMP 22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot Marie Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GAS3 (A142) polyclonal antibody detects endogenous levels of GAS3 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of GAS3 (A142) pAb at 1:500 dilution
Lane 1: MCF-7 whole cell lysate (40ug)
Lane 2: H1792 whole cell lysate (40ug)
Lane 3: A2780 whole cell lysate (40ug)
Lane 4: HCT116 whole cell lysate (40ug)
Lane 5: PC3 whole cell lysate (40ug)
Lane 6: PMVEC whole cell lysate (40ug)
Lane 7: CT-26 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of GAS3 (A142) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: PMP22; PMP-22; Growth arrest-specific protein 3; GAS-3; PMP22; GAS3 Growth Arrest Specific 3 HNPP Peripheral Myelin Protein 22 Trembler

Immunogen: Synthetic peptide, corresponding to amino acids 120-170 of Human GAS3.

Conjugate: Unconjugated

Modification: Unmodified