Product Description

Gastrin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66765-50, MB66765-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Gastrin, which is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, is a hormone whose main function is to stimμlate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Gastrin also stimμlates smooth muscle contraction and increases blood circμlation and water secretion in the stomach and intestine. Gastrin is regμlated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the ZollingerEllison syndrome. Gastrin maps to human chromosome 17q21.2. GastrinReleasing Peptide (GRP) stimμlates the release of gastrin as well as other gastrointestinal hormones, in addition to acting as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pμlmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems and, interestingly, is induced by retinoic acid. GRP is involved in several functions with the hypothalamus, and is thought to play a role in regμlating pituitary hormone secretion. GRP maps to human chromosome 18q21.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: GAS, Gastrin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Gastrin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of Gastrin protein.

Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01350

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only