GCK Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA25256-50, RA25256-100
Citations, Manuals and MSDS Available upon request.
Background: glucokinase (GCK) Homo sapiens Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI) . [provided by RefSeq, Apr 2009],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Alternative Names: GCK; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 2645
Protein MW (KDa): 55
SWISS: P35557
Source: Rabbit
Research Use Only