GCKR rabbit pAb - ES5494

GCKR rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5494-50, ES5494-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008],

Alternate Name: GCKR; Glucokinase regulatory protein; Glucokinase regulator

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Glucokinase Regulator. AA range:211-260

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 68kD

Human Gene ID: 2646

Human SWISS Prot NO: Q14397

Subcellular Location: Cytoplasm. Nucleus. Mitochondrion. Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.

Research Use Only