Product Description

GDN Polyclonal Antibody

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65479-50, BS65479-100

Swiss-Prot: P07093

Host: Rabbit

GDN Polyclonal Antibody-BS65479

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,

Applications: WB,

All Applications: WB=1:500-2000

Background: The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer’s disease.

Purification and Purity: affinity purified by Protein A

Specificity: GDN Polyclonal Antibody detects endogenous levels of GDN protein.

Bioworld Molecular Weight: 42 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti-GDN at 1/1000 dilution, Primary: Anti-GDN at 1/1000 dilution

Alternative Name: Glia derived nexin; Protease inhibitor 7; GDN; GDN_HUMAN; Glia-derived nexin; P17 antibody Peptidase inhibitor 7; Pi-7; Plasminogen activator inhibitor type 1, member 2; PN-1; PN1; PNI; Protease nexin 1; Protease nexin I; Serpin E2; Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; SERPINE 2; Serpine2.

Immunogen: KLH conjugated synthetic peptide derived from human GDN/SERPINE2:301-398/398

Modification: Unmodified

Conjugate: Unconjugated