Product Description

GDN Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65479-50, BS65479-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagμlation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellμlar invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer’s disease.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit

Host: Rabbit

Applications: WB

Alternate Names: Glia derived nexin, Protease inhibitor 7, GDN, GDN_HUMAN, Glia-derived nexin, P17 antibody Peptidase inhibitor 7, Pi-7, Plasminogen activator inhibitor type 1, member 2, PN-1, PN1, PNI, Protease nexin 1, Protease nexin I, Serpin E2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2, SERPINE 2, Serpine2.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human GDN/SERPINE2:301-398/398

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: GDN Polyclonal Antibody detects endogenous levels of GDN protein.

Molecular Weight: 42 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P07093

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only