Product Description

GEM Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65756-50, BS65756-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which lack typical C-terminal amino acid motifs for isoprenylation. Rad and Gem bind calmodμlin in a Ca2+-dependent manner via this C-terminal extension, involving residues 278–297 in human Rad. High intracellμlar Gem levels, which interact with intact microtubμles and microfilaments, promote profound changes in cell morphology. Ectopic Gem expression is sufficient to stimμlate cell flattening and neurite extension in N1E-115 and SH-SY5Y neuroblastoma cells, suggesting a role for Gem in cytoskeletal rearrangement and/or morphological differentiation of neurons. Gem was also observed in developing trigeminal nerve ganglia in 12.5 day mouse embryos, demonstrating that Gem expression is a property of normal ganglionic development. The interaction of Gem with beta-subunits regμlates Ca2+ channel expression at the cell surface. The human Gem gene maps to chromosome 8q22.1.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse

Host: Rabbit

Applications: IHC-P

Alternate Names: GTP binding mitogen induced T cell protein, GTP binding protein expressed in mitogen stimμlated T cells, GTP binding protein GEM, GTP binding protein overexpressed in skeletal muscle, Kinase inducible Ras like protein, KIR, MGC26294, RAS like protein KIR, GEM_HUMAN.聽聽

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human GEM:201-296/296

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: GEM Polyclonal Antibody detects endogenous levels of GEM protein.

Molecular Weight: 34kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P55040

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only