Product Description

GFI1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65757-50, BS65757-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Growth factor independent 1 (Gfi-1) is a transcriptional repressor that specifically binds to the DNA consensus sequence TAAATCAC(A/T)GCA. The carboxy-terminus of Gfi-1 contains six C2H2-type zinc finger motifs, and zinc fingers 3, 4 and 5 are required for the binding of Gfi-1 to its DNA binding site. Gfi-1 also contains a 20 amino acid SNAG domain which mediates transcriptional repression. It represses Bax at the mRNA and protein levels, resμlting in the inhibition of cell death. Gfi1 is expressed outside the lymphoid system in granμlocytes and activated macrophages. Gfi-1B, a related protein, is a transcriptional repressor primarily expressed in bone marrow and spleen. Gfi-1B is a direct repressor of the p21 promoter and the Socs 1 and 3 promoters. The genes encoding human Gfi-1 and Gfi-1B map to chromosome 1p22 and 9q34.3, respectively.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, Xenopus laevis

Host: Rabbit

Applications: WB

Alternate Names: GFI 1, GFI1, GFI-1, GFI1_HUMAN, Growth factor independence 1, growth factor independent 1, Growth factor independent protein 1, SCN2, Zinc finger protein 163, Zinc finger protein Gfi 1, Zinc finger protein Gfi-1, Zinc finger protein Gfi1, ZNF 163, ZNF163.聽

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human GFI1/ZNF163:301-400/422

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: GFI1 Polyclonal Antibody detects endogenous levels of GFI1 protein.

Molecular Weight: 49 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q99684

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only