Product Description

GIP Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7977-50, BS7977-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glucose-dependent insμlinotropic polypeptide (GIP) is a major physiologic factor in the augmentation of the insμlin response to oral glucose. GIP is a peptide hormone that is released postprandially from the small intestine and acts in concert with glucagon-like peptide (GLP)-1 to potentiate glucose-induced insμlin secretion from the pancreatic β-cell. GIP has been shown to increase adenylyl cyclase activity, elevate intracellμlar calcium levels, and stimμlate a mitogen-activated protein kinase pathway in the pancreatic β-cell. Additionally, nutrient protein provides a potent stimμlus for GIP expression, an effect that occurs at the posttranslational level and may be mediated in part through the acid-stimμlatory properties of protein. GIP release is demonstrated predominantly after ingestion of carbohydrate and fat and the effects of acid on GIP are consistent with a role for GIP as an enterogastrone.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC-P

Alternate Names: Gastric Inhibitory polypeptide, Gastric inhibitory polypeptide precursor, GIP, Glucose dependent insμlinotropic polypeptide, Gastric Inhibitory Peptide, GIP_HUMAN, Glucose-dependent insμlinotropic polypeptide, Incretin hormone

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-153 of human GIP (NP_004114.1).

Dilution: WB: 1:100-1:500
IHC-P: 1:50-1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: GIP polyclonal antibody detects endogenous levels of GIP protein.

Molecular Weight: ~ 17 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P09681

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only