GITRL Polyclonal Antibody-BS62529

GITRL Polyclonal Antibody

Catalogue Numbers: BS62529-50, BS62529-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UNG2

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB:1:500~1:1000

Background: GITRL (glucocorticoid-induced TNF-related ligand), a polypeptide encoded by a human umbilical endothelial cell cDNA, is a member of the TNF (tumor necrosis factor) superfamily. GITRL has a type 2 transmembrane topology that is characteristic of the TNF family. The TNF superfamilies regulate diverse biological functions, including cell proliferation, differentiation and survival. GITRL is found on vascular endothelial cells and in several peripheral tissues (small intestine, ovary, testis and kidney), where it may modulate T lymphocyte survival. The GITR receptor recognizes GITRL and the two interact to regulate NFκB activation. The ligand-receptor pair of GITRL-GITR protects cells against AICD (activation-induced cell death).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GITRL polyclonal antibody detects endogenous levels of GITRL protein.

Extra Notes: Western blot (WB) analysis of GITRL polyclonal antibody at 1:500 dilution
LaneA:SK-OVCAR3 whole cell lysate
LaneB:A2780 whole cell lysate
LaneC:HEK293T whole cell lysate
LaneD:The Testis tissue lysate of Mouse
LaneE:The Testis tissue lysate of Rat

Bioworld Molecular Weight: ~ 20 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL

Immunogen: Synthetic peptide, corresponding to Human GITRL.

Conjugate: Unconjugated

Modification: Unmodified