Product Description

Gli3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90576-50, BS90576-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P10071(Human)

Host: Rabbit

Reactivity: Human

Applications: WB ICC

All Applications: WB:1:500-1:2,000
ICC:1:50-1:100

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-3 (GLI family zinc finger 3), also known as GLI3FL (GLI3 full length protein), PHS, ACLS, GCPS, PAPA, PAPB, PAPA1 or PPDIV, is a 1,580 amino acid nuclear and cytoplasmic protein that acts as both a transcriptional activator and a repressor of the Sonic hedgehog (Shh) pathway. A member of the GLI C2H2-type zinc-finger protein family, GLI-3 is encoded by a gene that maps to human chromosome 7p14.1. Defects in the GLI-3 gene are the cause of a disorder known as Greig cephalo-poly-syndactyly syndrome (GCPS), which affects limb and craniofacial development.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Gli3 on PC-3M cell lysate using anti-Gli3 antibody at 1/1,000 dilution.

Bioworld Molecular Weight: 190 kDa

Specificity: Gli3 polyclonal antibody detects endogenous levels of Gli3 protein.

Alternative Name: GLI3-190, GLI3FL, GLI3-83, GLI3, ACLS, DNA binding protein, GCPS, Gli 3, GLI family zinc finger 3, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI Kruppel family member GLI3, GLI3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3, GLI3FL, Glioma associated oncogene family zinc finger 3, Oncogene GLI3, PAP A, PAPA 1, PAPA, PAPA1, PAPB, PHS, PPD IV, PPDIV, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3, Zinc finger protein GLI3,

Immunogen: Recombinant protein within human Gli3 aa 1300-1600.

Conjugate: Unconjugated

Modification: Unmodified