Glucagon Receptor (K136) Polyclonal Antibody-BS2718

Glucagon Receptor (K136) Polyclonal Antibody

Catalogue Numbers: BS2718-50, BS2718-100

Sizes: 50µl, 100µl

Alternative Name: Glucagon receptor; GL-R; GCGR

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P47871

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IF

All Applications: WB: 1:500~1:1000
IF: 1:50~1:200

Background: Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Glucagon Receptor (K136) polyclonal antibody detects endogenous levels of Glucagon Receptor protein.

Bioworld Molecular Weight: ~ 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Glucagon Receptor (K136) polyclonal antibody at 1:500 dilution
Lane 1: AML-12 whole cell lysate(40ug)
Lane 2: H9C2 whole cell lysate(40ug)
Lane 3: A549 whole cell lysate(40ug)
Lane 4: HEK293T whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Glucagon Receptor.

Conjugate: Unconjugated

Modification: Unmodified