Glucocorticoid Receptor Polyclonal Antibody - E-AB-70157

Glucocorticoid Receptor Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-70157-60, E-AB-70157-120, E-AB-70157-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: Glucocorticoid Receptor

Target Synonym: GCCR; GCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; GRL; Grl1; nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3; group C; member 1 (glucocorticoid receptor)

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P04150,P06536,P06537

Background: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.

Concentration: 1.3 mg/mL

Immunogen: Recombinant proteincorresponding to Mouse Glucocorticoid receptor

Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:1000, IHC 1:500-1:1000

Calculated MW: 91kDa

Observed MW: 91kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only