Glucocorticoid receptor Polyclonal Antibody - RA25344

Glucocorticoid receptor Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA25344-50, RA25344-100

Citations, Manuals and MSDS Available upon request.

Background: nuclear receptor subfamily 3 group C member 1 (NR3C1) Homo sapiens This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking pat

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:1000-3000

Alternative Names: NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 2908

Protein MW (KDa): 80-97

SWISS: P04150

Source: Rabbit

Research Use Only