Product Description

Glucose 6 phosphatase 2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65759-50, BS65759-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glucose-6-phosphatase (G6Pase), is a mμlticomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticμlum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regμlation of islet metabolism and in insμlin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resμlting from insμlin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticμlum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep

Host: Rabbit

Applications: WB

Alternate Names: G 6 Pase 2, G 6 Pase2, G6Pase 2, G6Pase2, G6PC 2, G6pc rs, G6pcrs, Glucose 6 phosphatase 2, Glucose 6 phosphatase, catalytic, 2, Glucose 6 phosphatase, catalytic, related, Glucose 6 phosphate catalytic 2, Islet specific G6CP related protein, Islet specific glucose 6 phosphatase, Islet specific glucose 6 phosphatase catalytic subunit related protein, G6PC2_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase 2/IGRP:31-130/355

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: Glucose 6 phosphatase 2 Polyclonal Antibody detects endogenous levels of Glucose 6 phosphatase 2 protein.

Molecular Weight: 42 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NQR9

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only