GluR-δ2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA25360-50, RA25360-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: glutamate ionotropic receptor delta type subunit 2 (GRID2) Homo sapiens The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IF/ICC, ELISA Alternate Names: GRID2, GLURD2, Glutamate receptor delta-2 subunit, GluR delta-2 subunit Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. Molecular Weight: 113 Protein Molecular Weight (kDa): 113 Storage: -20°C/1 year Human Gene ID: 2895 Human SwissProt Number: O43424 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only