GluR-2 (Phospho-Tyr876) Polyclonal Antibody - RA25353

GluR-2 (Phospho-Tyr876) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA25353-50, RA25353-100 Citations, Manuals and MSDS Available upon request. Background: glutamate ionotropic receptor AMPA type subunit 2 (GRIA2) Homo sapiens Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca (2+) . Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC-p 1:50-200, WB 1:500-2000 Alternative Names: Glutamate receptor 2 (GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic, AMPA 2;GluA2) Applications: IHC-p; IF (paraffin section) ; WB Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 2891 Protein MW (KDa): 99 SWISS: P42262 Source: Rabbit Research Use Only