Product Description

GluR1 (phospho-S863) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: BS4793-50, BS4793-100

Swiss-Prot: P42261

Host: Rabbit

GluR1 (phospho-S863) Polyclonal Antibody-BS4793

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human

Applications: WB, IHC

All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200

Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-GluR1 (S863) polyclonal antibody detects endogenous levels of GluR1 protein only when phosphorylated at Ser863.

Bioworld Molecular Weight: ~ 102 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of p-GluR1 (S863) pAb pAb at 1:500 dilution
Lane 1: HEK293T whole cell lysate (40ug)
Lane 2: K562 whole cell lysate (40ug)
Lane 3: U-87MG whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of p-GluR1 (S863) pAb pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Alternative Name: Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; GluRA; GluRK1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1; GLUR1

Immunogen: Synthetic phosphopeptide derived from human GluR1 around the phosphorylation site of Serine 863.

Modification: Phosphorylation

Conjugate: Unconjugated