Product Description

Glut 4 (R271) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3680-50, BS3680-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: In response to insμlin, Glut4 is quickly shuttled from an intracellμlar storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to insμlin. Glut1 and Glut4 are twelve pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellμlar localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 nμll mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellμlar glucose, fat metabolism and prolonged longevity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Solute carrier family 2, facilitated glucose transporter member 4, Glucose transporter type 4, insμlin-responsive, GLUT-4, GLUT4, SLC2A4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human Glut 4.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Glut4 (R271) polyclonal antibody detects endogenous levels of Glut4 protein.

Molecular Weight: ~ 45-55 kDa

Pathway: Warburg Effect, Insμlin &Glucose Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P14672

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only