Glypican-3 rabbit pAb - ES3936

Glypican-3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3936-50, ES3936-100

Citations, Manuals and MSDS Available upon request.

Background: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],

Alternate Name: GPC3; OCI5; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human GPC3. AA range:461-510

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 70kD

Human Gene ID: 2719

Human SWISS Prot NO: P51654

Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Research Use Only